In the present study, we have used spray drying technology for drying of processed Guggulu. Monitoring these parameters will help to control batch to batch variations. Drying process impacts the quality of the formulation, and hence, practical implementation of these practices at commercial manufacturing needs critical process control parameters. In the classical preparations of Guggulu, different processing methods for different preparations are mentioned. Spray dried TG obtained above was formulated using excipient combinations as per Tables Tables1 1 and and2 2. The dried sample was subjected to high-performance liquid chromatography analysis. The dried material was collected in double-lined food grade low-density polyethylene bags, sealed, and stored in high- density polyethylene container. Then, the material was removed, and filtrate ( Shuddha Guggulu) was spray dried using spray dryer at 180☌ as inlet and 110☌ as outlet temperature. This vessel was then heated at a temperature between 85☌ and 95☌ for 3 h. The process involved use 5 kg of Guggulu which was tied in 100 µm muslin cloth and suspended in a SS304 vessel containing Triphala Kwatha. The filtrate was further used to process Guggulu. The extract was filtered using 100 µm filter cloth. Powdered fruit blend (5 kg) was boiled in 40 L of demineralized water for 3 h using extraction vessel with a fixed temperature ranging from 85☌ to 95☌. In the present study, an attempt is made to adopt TG into a tablet formulation meeting the United States Pharmacopeia (USP) requirements. This underlines the need to translate this Vati preparation in modern pharmaceutical dosage forms into pharmacopeial tablet formulation. Furthermore, with increase in demand globally, there is an unmet challenge to meet global regulations. However, in modern practice, to fulfill market demand, an industrial approach for the traditional manufacturing process is warranted. Traditional texts describe in detail about the manufacturing process for the same. This approach will help to control the process parameters during manufacturing.Īmong the Guggulu preparations, TG is one of the widely used preparations. To achieve this, a contemporary approach to one of the most renowned formulations mentioned in Ayurveda Triphala Guggulu (TG) was taken up as a model. With an increase in global demand for herbal medicine, it is now important to ensure consistency in quality of products from batch to batch.
Due to globalization and increased awareness, the traditional medicine usage is increasing every year. Ayurveda is one of the oldest systems of medicine, which is in practice since ages. Herbs and herbal medicines are preferred by people since ages, and about 80% of the global population still rely on herbs and herbal remedies for chronic ailments.